Progesterone Receptor

NR3C3

Progesterone Receptor

Related Products

Progesterone receptor (PR) is a member of the steroid/thyroid hormone-retinoid receptor superfamily of ligand-activated nuclear transcription factors. Progesterone receptor plays a vital role in female reproductive tissue development, differentiation, and maintenance.

Progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. Progesterone receptor, such as progesterone, induces conformation changes in PR ligand binding domain (LBD), thus mediates subsequent gene regulation cascades.

In humans, the biological response to progesterone is mediated by two distinct forms of the progesterone receptor (human PR-A and PR-B).

Progesterone Receptor Related Products (134)
Antibodies (2)

By Effects:	Inhibitors (10) Ligand (1) Agonists (71) Antagonists (20) Activators (7) Modulators (6)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N0437S1

Progesterone-¹³C₅	Agonist
Progesterone-¹³C₅ is the ¹³C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.

HY-111614R

Melengestrol acetate (Standard)	Activator
Melengestrol acetate (Standard) is the analytical standard of Melengestrol acetate. This product is intended for research and analytical applications. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research.

HY-111614S1

Melengestrol acetate-d₂	Activator
Melengestrol acetate-d₂ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].

HY-B0110R

Gestodene (Standard)	Agonist
Gestodene (Standard) is the analytical standard of Gestodene. This product is intended for research and analytical applications.

HY-B1710S

Norethindrone acetate-d₈
Norethindrone acetate-d₈ is the deuterium labeled Norethindrone acetate. Norethindrone acetate is a female hormone used for the research of endometriosis[1]. Norethindrone acetate-d8 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W013172R

Norgestimate (Standard)
Norgestimate (Standard) is the analytical standard of Norgestimate. This product is intended for research and analytical applications. Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive.

HY-N0347R

17α-Hydroxyprogesterone acetate (Standard)	Inhibitor
17α-Hydroxyprogesterone acetate (Standard) is the analytical standard of 17α-Hydroxyprogesterone acetate. This product is intended for research and analytical applications. 17α-Hydroxyprogesterone acetate possesses progestational activity. 17α-Hydroxyprogesterone acetate has antiinflammatory effects at the murine maternal-fetal interface.

HY-N11224

Pregnanetriol		99.8%
Pregnanetriol is a metabolite of 17α-Hydroxyprogesterone (HY-B0891). 17α-Hydroxyprogesterone is an endogenous progesterone.

HY-123047S

Tibolone-d₅	Agonist
Tibolone-d₅ is deuterium labeled Tibolone. Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research.

HY-14465

PF 02367982	Antagonist
PF 02367982 is a potent and select progesterone receptor (PR) antagonist with an IC₅₀ value of 47.3 nM. PF 02367982 has oral activity.

HY-14901

Telapristone	Antagonist
Telapristone is a Progesterone antagonist. Telapristone can be used in the study of uterine fibroids and endometriosis.

HY-16508R

Ulipristal acetate (Standard)	Antagonist
Ulipristal acetate (Standard) is the analytical standard of Ulipristal acetate. This product is intended for research and analytical applications. Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma.

HY-111302

Norgestrienone	Agonist
Norgestrienone is a progestin receptor agonist. Norgestrienone is commonly used as a progesterone compound in birth control pills and can be combined with ethinylestradiol. Norgestrienone is a click chemical. It contains Alkyne groups and can undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Azide groups. Norgestrienone can be used in the study of hereditary angioneurotic edema.

HY-B1710R

Norethindrone acetate (Standard)
Norethindrone acetate (Standard) is the analytical standard of Norethindrone acetate. This product is intended for research and analytical applications. Norethindrone acetate is a female hormone used for the research of endometriosis. Norethindrone acetate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W703425

17α-Ethynyl-19-nor-Δ-5(6)-androsten-17β-ol-3-one	Agonist
17α-Ethynyl-19-nor-Δ-5(6)-androsten-17β-ol-3-one (delta-5(6)-Norethindrone), an impurity of Norethindrone, is an anabolic agent. Norethindrone is a progestin athat can be used for endometriosis research.

HY-B0554S1

Norethindrone-¹³C₂	Agonist
Norethindrone-¹³C₂ (Norethisterone-¹³C₂) is the ¹³C labeled Norethindrone (HY-B0554). Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.

HY-16508S1

Ulipristal acetate-d₃	Antagonist
Ulipristal acetate-d₃ (CDB-2914-d₃) is deuterium labeled Ulipristal acetate. Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma.

HY-106140A

Asoprisnil ecamate	Modulator
Asoprisnil ecamate (J 956) is an orally active antiprogestin, and can be used for contraception.

HY-168759

11α-Hydroxytestosterone	Ligand
11α-Hydroxytestosterone is a deriviative of Hydrocortisone (HY-N0583), with the relative binding affinity to progesterone receptor of 9% (comparing to R5020 (HY-119384) 100%). 11α-Hydroxytestosterone inhibits the growth and differentiation of human decidual cells in culture.

HY-106299

Lilopristone	Antagonist
Lilopristone (ZK98734) is a progesterone antagonist with a potential to induce menstruation, inhibit nidation, and terminate pregnancy. Lilopristone blocks progesterone action at the endometrium as well as decreases progesterone bioavailability, and can be utilized in antifertility research.

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Progesterone Receptor

Progesterone Receptor

Progesterone Receptor Related Products (134)

Antibodies (2)

Progesterone Receptor Related Products (134):